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OPEN POSITIONS

SCIENTIST, CAR-T ENGINEERING

Location: St. Louis

Job Description

Looking for a Cell Biologist or Immunologist to join a team developing novel and innovative engineered T-cell-based therapies for oncology. The initial focus of this role is to establish a research-scale production of novel engineered T-cells, and to work closely with fellow synthetic biology scientists and disease area scientists to evaluate the activity and efficacy of novel candidate cellular therapeutics. A PhD and postdoctoral experience in cell biology, immunology, or bioprocess development is required. Experience in the biotechnology industry and the CAR-T field in particular is highly desirable.

The position level will be commensurate with the candidate’s qualifications and experience. Demonstrable expertise in one or more of the following areas: T-cell growth and differentiation, viral vector transduction of T-cells, mammalian cell process development, flow cytometry, gene-editing and cell purification methodologies. The successful candidate will possess a strong publication record, have excellent communication skills, attention to detail, demonstrate independent thinking, understand process development of cellular therapies, and be able to thrive in a collaborative and fast-paced team environment.

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other federal, state or local protected class.

OPEN POSITIONS

Associate Director, Analytical Development

Location: St. Louis

Job Description

Associate Director of Analytical Development

Location: St. Louis

Join the Chemical, Manufacturing, and Controls (CMC) department of a fast-paced startup based in St. Louis with the opportunity to drive analytical development activities of novel therapies for treating rare diseases.  The associate director of analytical development role will be responsible for assay development and qualification, supporting QC activities at external contract manufacturing/research organizations (CMO/CRO), and ownership of analytical aspects of regulatory filings.

Primary Responsibilities

– Oversee the design and execution of assay development and optimization experiments, data analysis, and generation of development reports.

– Work closely with R&D to ensure smooth transfer from discovery to CMC.

– Support regulatory activities, including authoring IND sections.

– Lead the transfer of analytical methods to external CMO/CRO.

– Work with process development (PD) to provide analytical support of PD activities.

Preferred Qualifications

– Degree in biology, engineering, or related field. 10+ years industry experience with a BS, 7+ years with an MS, or 4+ years with a PhD.

– Experience managing direct reports.

– Gene and cell therapy analytical development, including design of experiments.

– Familiarity with aseptic technique, GxP, and assay qualification/validation.

– Strong knowledge of flow cytometry, qPCR, and cell-based assays.

– Proficiency with statistical analysis software for experimental design and data analysis.

– Analytical technical transfer experience to a CMO/CRO and protocol creation/review.

– Mammalian cell culture experience, ideally with T cells and NK cells.

– Experience with writing/reviewing/data verifying regulatory documents.

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other federal, state or local protected class.

OPEN POSITIONS

Bioinformatics Scientist

Location: St. Louis

Job Description

Bioinformatics Scientist

We are seeking a talented and motivated bioinformatics scientist to make important contributions to cutting-edge cellular therapies. This position will work directly with the Head of Genomic Analysis to develop, implement, and manage genome analysis capability that will be used to support Wugen’s product pipeline. Specific projects will involve processing, analyzing, and interpretation of next-generation sequencing (NGS) data for genome sequencing and gene expression quantification that will be used to establish the efficacy and safety of cellular products for regulatory approval.

Primary Responsibilities

  • Work with the Head of Genomic Analysis to implement existing sequence data analysis pipelines in a new computational environment.
  • Manage sequence data analysis and prepare reports for review.
  • Contribute to documentation of analysis and results for regulatory submissions.

Preferred Qualifications

  • Proficiency in the Unix-based operating system is required. Experience with basic system administration is preferred.
  • Experience working in cloud environments (e.g., AWS/EC2/Batch, or Google Cloud) would be highly valued.
  • Proficient in object-oriented Perl, Python, R and/or similar scripting languages.
  • Previous experience analyzing and/or managing next-generation sequencing data analysis would be ideal, including basic sequencing alignment and analysis tools. Experience with workflow management languages (CWL or WDL) would be highly valued.
  • Some knowledge of basic statistics and hypothesis testing procedures would be ideal.
  • Experience using common software (Excel, R, Prism, Powerpoint, etc) for preparing and presenting reports, figures, and graphic data representations.

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other federal, state or local protected class.

OPEN POSITIONS

Associate Scientist/Engineer, Product Development

Location: St. Louis

Job Description

Associate Scientist/Engineer – Product Development / Technology Transfer

Join a fast-paced startup based in St. Louis with the opportunity to help drive process development activities of novel therapies for treating rare diseases.  The product development (PD) associate scientist/engineer role will focus on the transfer and implementation of Wugen-developed processes at contract manufacturing organizations (CMOs).  This role will also support in-house PD research and developing/running analytical methods.

Primary Responsibilities

  • Support manufacturing at an external CMO.
  • Work closely with research and development to ensure smooth transfer from discovery through development and into manufacturing/QC.
  • Support process development studies.
  • Support the development and running of analytical methods.
  • Write and/or review development protocols and reports.
  • Support IND activities, including reviewing, data verification, and potentially authoring sections.

Preferred Qualifications

  • Degree in engineering, biology, or related field. 4+ years experience with a BS, 2+ years with an MS; industry experience strongly
  • Gene and cell therapy manufacturing, with GMP manufacturing or QC experience.
  • Technical transfer experience to a CMO and batch record creation/review.
  • Experience culturing T cells and NK cells.
  • Good sterile technique in a biosafety cabinet, hands on experience with the CliniMACS Prodigy system, and experience with formulation and cryopreservation with a controlled rate freezer.
  • Statistical analysis proficiency for data analysis.
  • Flow cytometry, qPCR, and cell-based assay experience considered a plus.

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other federal, state or local protected class.

OPEN POSITIONS

Scientist- Genome Editing

Location: St. Louis

Job Description

We are seeking a Cell Biologist or Immunologist to join a team developing novel and innovative engineered cell-based therapies for oncology. The initial focus of the individual in this role is to develop a system for genome editing of engineered lymphocytes.

He/she will work closely with fellow synthetic biology scientists to evaluate the activity and efficacy of novel candidate cellular therapeutics.

A PhD in cell biology or immunology is required.

Compensation will be commensurate with the successful candidate’s qualifications and experience.

Key expertise in one or more of the following areas is highly desired:

Gene editing, Cas9/CRISPR, shRNA, high-throughput screening, human lymphocyte culture, mouse efficacy models, RNA-Seq, viral vector transduction of lymphocytes, flow cytometry, and cell purification methodologies.

The successful candidate will possess a strong publication record, have excellent communication skills, be attentive to detail, demonstrate independent thinking, understand process development of cellular therapies, and be able to thrive in a collaborative and fast-paced team environment.

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other federal, state or local protected class.

OPEN POSITIONS

LAB MANAGER – JOB FILLED

Location: St. Louis

Job Description

The product development (PD) lab manager role is part of the Chemical Manufacturing and Controls (CMC) department, and will focus on maintaining the inventory of lab supplies and supporting in-house PD research.

Primary Responsibilities

  • Maintain an up-to-date inventory management system in SciNote for standard lab raw materials and consumables. Maintain an adequate supply of commonly used consumables.
  • Place and track orders, and notify the appropriate parties of deliveries.
  • Set up accounts with vendors.
  • Review and approve invoices.
  • Oversee lab operations to ensure compliance with safety regulations.
  • Help maintain lab readiness and cleanliness.
  • Assist with experiments and assays, including reagent preparation, data collection, maintenance of equipment, cell culture, sampling, etc.

Preferred Qualifications

  • Associate’s degree with 2+ years relevant experience, or Bachelor’s degree.
  • Must be detail-oriented with regard to inventory management.
  • Able to maintain organized records and diligently stay on top of outstanding orders.
  • Familiarity with Microsoft Office.
  • Familiarity with general lab equipment, such as biosafety cabinets, centrifuges, flow cytometers, pipettors, etc. 
  • Cell culture, aseptic technique, and assay experience.

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other federal, state or local protected class.

OPEN POSITIONS

Scientist/Engineer, Process Development

Location: St. Louis

Job Description

Location: St. Louis

The process development (PD) scientist/engineer role will focus on conducting in-house PD research, developing analytical methods, and supporting external contract manufacturing organization (CMO) activities. Multiple roles are available.

Primary Responsibilities

  • Design and conduct process development and process optimization experiments, analyze data, and generate development reports.
  • Work closely with research and development to ensure smooth transfer from the lab to manufacturing/QC.
  • Support IND activities, including reviewing, data verification, and potentially authoring sections.
  • Support manufacturing at an external CMO.
  • Assist in setting up new equipment.
  • Develop and run analytical methods.

Preferred Qualifications

  • Degree in engineering, biology, or related field. 8+ years experience with a BS, 5+ years with an MS, or 1+ years with a Ph.D.; industry experience preferred.
  • Gene and cell therapy process development, including design of experiments.
  • Experience culturing T cells and NK cells.
  • Good sterile technique in a biosafety cabinet, hands on experience with the CliniMACS Prodigy system, and experience with formulation and cryopreservation with a controlled rate freezer.
  • Gene and cell therapy manufacturing, ideally having worked in a cGMP manufacturing suite.
  • Statistical analysis proficiency for data analysis.
  • Technical transfer experience to a CMO and batch record creation/review.
  • Flow cytometry, qPCR, and cell-based assay experience.
  • Experience with writing/reviewing/data verifying regulatory documents.
 

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other federal, state or local protected class.

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