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OPEN POSITIONS

SCIENTIST, CAR-T ENGINEERING

Location: St. Louis

Job Description

Looking for a Cell Biologist or Immunologist to join a team developing novel and innovative engineered T-cell-based therapies for oncology. The initial focus of this role is to establish a research-scale production of novel engineered T-cells, and to work closely with fellow synthetic biology scientists and disease area scientists to evaluate the activity and efficacy of novel candidate cellular therapeutics. A PhD and postdoctoral experience in cell biology, immunology, or bioprocess development is required. Experience in the biotechnology industry and the CAR-T field in particular is highly desirable.

The position level will be commensurate with the candidate’s qualifications and experience. Demonstrable expertise in one or more of the following areas: T-cell growth and differentiation, viral vector transduction of T-cells, mammalian cell process development, flow cytometry, gene-editing and cell purification methodologies. The successful candidate will possess a strong publication record, have excellent communication skills, attention to detail, demonstrate independent thinking, understand process development of cellular therapies, and be able to thrive in a collaborative and fast-paced team environment.

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other fereral, state or local protected class.

OPEN POSITIONS

LAB MANAGER

Location: St. Louis

Job Description

The product development (PD) lab manager role is part of the Chemical Manufacturing and Controls (CMC) department, and will focus on maintaining the inventory of lab supplies and supporting in-house PD research.

Primary Responsibilities

  • Maintain an up-to-date inventory management system in SciNote for standard lab raw materials and consumables. Maintain an adequate supply of commonly used consumables.
  • Place and track orders, and notify the appropriate parties of deliveries.
  • Set up accounts with vendors.
  • Review and approve invoices.
  • Oversee lab operations to ensure compliance with safety regulations.
  • Help maintain lab readiness and cleanliness.
  • Assist with experiments and assays, including reagent preparation, data collection, maintenance of equipment, cell culture, sampling, etc.

Preferred Qualifications

  • Associate’s degree with 2+ years relevant experience, or Bachelor’s degree.
  • Must be detail-oriented with regard to inventory management.
  • Able to maintain organized records and diligently stay on top of outstanding orders.
  • Familiarity with Microsoft Office.
  • Familiarity with general lab equipment, such as biosafety cabinets, centrifuges, flow cytometers, pipettors, etc. 
  • Cell culture, aseptic technique, and assay experience.

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other fereral, state or local protected class.

OPEN POSITIONS

Scientist/Engineer, Process Development

Location: St. Louis

Job Description

Location: St. Louis

The process development (PD) scientist/engineer role will focus on conducting in-house PD research, developing analytical methods, and supporting external contract manufacturing organization (CMO) activities. Multiple roles are available.

Primary Responsibilities

  • Design and conduct process development and process optimization experiments, analyze data, and generate development reports.
  • Work closely with research and development to ensure smooth transfer from the lab to manufacturing/QC.
  • Support IND activities, including reviewing, data verification, and potentially authoring sections.
  • Support manufacturing at an external CMO.
  • Assist in setting up new equipment.
  • Develop and run analytical methods.

Preferred Qualifications

  • Degree in engineering, biology, or related field. 8+ years experience with a BS, 5+ years with an MS, or 1+ years with a Ph.D.; industry experience preferred.
  • Gene and cell therapy process development, including design of experiments.
  • Experience culturing T cells and NK cells.
  • Good sterile technique in a biosafety cabinet, hands on experience with the CliniMACS Prodigy system, and experience with formulation and cryopreservation with a controlled rate freezer.
  • Gene and cell therapy manufacturing, ideally having worked in a cGMP manufacturing suite.
  • Statistical analysis proficiency for data analysis.
  • Technical transfer experience to a CMO and batch record creation/review.
  • Flow cytometry, qPCR, and cell-based assay experience.
  • Experience with writing/reviewing/data verifying regulatory documents.
 

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Wugen is an equal opportunity employer and does not discriminate against applicants due to race, ethnicity, gender, veteren status, or on the basis of disability or any other fereral, state or local protected class.

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