DEVELOPING A MORE EFFECTIVE CAR-T THERAPY
April 30, 2019
Modeling Sézary Syndrome for Immunophenotyping and Anti-Tumor Effect of UCART and Long-Acting Interleukin-7 Combination Therapy
A Long-Acting Pharmacological Grade Interleukin-7 Molecule Logarithmically Accelerates UCART Proliferation, Differentiation, and Tumor Killing
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An “off-the-shelf” fratricide-resistant CAR-T for the Treatment of T-cell hematologic malignancies
T-cell malignancies represent a group of hematologic cancers with high rates of relapse and mortality in patients for whom no effective targeted therapies exist. The shared expression of target antigens between chimeric antigen receptor (CAR) T-cells and malignant T-cells has limited the development.