wugen

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Wugen is an Equal Opportunity Employer and does not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.

We are always looking for energetic, dynamic, solution-oriented people who enjoy working in the biotech industry. Share our team-based mission of discovering ground-breaking cancer treatments.

Open Positions

Job description

Scientist, CAR-T engineering

Location: St. Louis

Looking for a Cell Biologist or Immunologist to join a team developing novel and innovative engineered T-cell-based therapies for oncology. The initial focus of this role is to establish a research-scale production of novel engineered T-cells, and to work closely with fellow synthetic biology scientists and disease area scientists to evaluate the activity and efficacy of novel candidate cellular therapeutics. A PhD and postdoctoral experience in cell biology, immunology, or bioprocess development is required. Experience in the biotechnology industry and the CAR-T field in particular is highly desirable.

The position level will be commensurate with the candidate’s qualifications and experience. Demonstrable expertise in one or more of the following areas: T-cell growth and differentiation, viral vector transduction of T-cells, mammalian cell process development, flow cytometry, gene-editing and cell purification methodologies. The successful candidate will possess a strong publication record, have excellent communication skills, attention to detail, demonstrate independent thinking, understand process development of cellular therapies, and be able to thrive in a collaborative and fast-paced team environment.

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Job description

Analytical Development Lead

Location: St. Louis

Join a fast-paced startup based in St. Louis with the opportunity to drive analytical development activities of novel therapies for treating rare diseases.  The analytical development (AD) lead role will focus on assay development and qualification, and support QC activities at external contract manufacturing/research organizations (CMO/CRO).

 

Primary Responsibilities

  • Assist in setting up a development lab.
  • Design and conduct assay development and optimization experiments, analyze data, and generate development reports.
  • Work closely with research and development to ensure smooth transfer from the lab to clinical manufacturing.
  • Support IND activities, including authoring sections.
  • Support analytical at external CRO and CMO.
  • Work with process development (PD) and run assays in support of PD activities.

 

Preferred Qualifications

  • Degree in biology, engineering, or related field. 8+ years industry experience with a BS, 6+ years with an MS, or 3+ years with a PhD.
  • Gene and cell therapy analytical development, including design of experiments.
  • Good sterile technique in a biosafety cabinet, hands on experience with the flow cytometry, qPCR, and cell-based assays.
  • Gene and cell therapy manufacturing, ideally having experience in a GLP QC lab.
  • Statistical analysis proficiency for data analysis.
  • Analytical technical transfer experience to a CMO and protocol creation/review.
  • Mammalian cell culture experience and familiarity with a CliniMACS Prodigy system.
  • Experience with writing/reviewing/data verifying regulatory documents.

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Job description

SCIENTIST/ENGINEER- PROCESS DEVELOPMENT

Location: St. Louis

Join a fast-paced startup based in St. Louis with the opportunity to help drive process development activities of novel therapies for treating rare diseases.  The process development (PD) scientist/engineer role will focus on in-house PD research and support external contract manufacturing organization (CMO) activities.

 

Primary Responsibilities

  • Assist in setting up a PD lab.
  • Design and conduct process development and process optimization experiments, analyze data, and generate development reports.
  • Work closely with research and development to ensure smooth transfer from the lab to manufacturing.
  • Support IND activities, including potentially authoring sections.
  • Support manufacturing at an external CMO.
  • Work with analytical development and run routine assays.

 

Preferred Qualifications

  • Degree in engineering, biology, or related field. 5+ years industry experience with a BS, 3+ years with an MS, or 0+ years with a PhD.
  • Gene and cell therapy process development, including design of experiments.
  • Good sterile technique in a biosafety cabinet, hands on experience with the CliniMACS Prodigy system, and experience with formulation and cryopreservation with a controlled rate freezer.
  • Gene and cell therapy manufacturing, ideally having worked in a cGMP manufacturing suite.
  • Statistical analysis proficiency for data analysis.
  • Technical transfer experience to a CMO and batch record creation/review.
  • Flow cytometry, qPCR, and cell-based assay experience.
  • Experience with writing/reviewing/data verifying regulatory documents.

 

Apply Now
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