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Wugen is an Equal Opportunity Employer and does not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.

We are always looking for energetic, dynamic, solution-oriented people who enjoy working in the biotech industry. Share our team-based mission of discovering ground-breaking cancer treatments.

Open Positions

Job description

Scientist, CAR-T engineering

Location: St. Louis

Looking for a Cell Biologist or Immunologist to join a team developing novel and innovative engineered T-cell-based therapies for oncology. The initial focus of this role is to establish a research-scale production of novel engineered T-cells, and to work closely with fellow synthetic biology scientists and disease area scientists to evaluate the activity and efficacy of novel candidate cellular therapeutics. A PhD and postdoctoral experience in cell biology, immunology, or bioprocess development is required. Experience in the biotechnology industry and the CAR-T field in particular is highly desirable.

The position level will be commensurate with the candidate’s qualifications and experience. Demonstrable expertise in one or more of the following areas: T-cell growth and differentiation, viral vector transduction of T-cells, mammalian cell process development, flow cytometry, gene-editing and cell purification methodologies. The successful candidate will possess a strong publication record, have excellent communication skills, attention to detail, demonstrate independent thinking, understand process development of cellular therapies, and be able to thrive in a collaborative and fast-paced team environment.

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Job description

Associate Scientist/Scientist, Process Development and GMP Manufacturing

Location: Flexible

Looking for an experienced process development Associate Scientist/Scientist for our cell therapy programs. A successful applicant will have prior experience with gene modified cell therapies and be comfortable working in a fast-paced environment. Applicants should have current knowledge of genetically modified T-Cell therapies, comfortable with the pre-clinical process development and GMP tech transfer process, and familiarity with analytical methods development and implementation.

Qualifications: BS or MS in Chemical Engineering, Biochemistry, Molecular & Cell Biology, Immunology or the related field with at least 2 years of industry experience OR a PhD with at least 3 years of industry experience is required.  Experience with prior Gene & Cell Therapy manufacturing and working in a GMP environment preferred.  Demonstrable expertise in one or more of the following areas: T-cell growth and differentiation, viral vector transduction of T-cells, mammalian cell process development, flow cytometry, gene-editing and cell purification methodologies.

Responsibilities include, but are not limited to: Actively contribute to development, implementation, characterization and successful execution of robust CAR-T manufacturing processes. Support clinical-scale non-GMP/ GMP IND-enabling manufacturing operations, including Tech Transfer from CMO and support of successful GMP manufacturing of clinical material. Ensure high-quality, timely documentation in electronic laboratory notebooks and Technical Reports.  Ensure data integrity and maintain compliance with general laboratory operations, all appropriate SOPs for laboratory work, data recording, and laboratory equipment.

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